Tag Archives: LDN

My Progress with LDN – Part II


Since my last post where I spoke about my beginning LDN therapy, I have turned a corner towards feeling better. Much of the pain and strange neurological symptoms from my injuries have diminished enough to be noticed.  The beautiful ‘side effect’ of this 100% safe and non-addictive compounded medication is that all anxiety has left.  I’m up to 3mg at night now.  I believe that I’ll be going up a bit again on Monday, when my doctor returns from a trip.  Hopefully, that will be my dose and I can look forward to continued lessening of my chronic pain and uncomfortable neurological symptoms.

This medication saves lives and, if more doctors were told about it’s efficacy, people wouldn’t have to be given dangerous opiates and other addictive drugs.  I recommend it highly and ask you to call your local ‘compounding’ pharmacies for a physician recommendation. Not all doctors prescribe this because they are not licensed to do so.  They must know how to detail the compounding to the pharmacist.  The pharmacist also has to be licensed to compound.  It sound like a chore to find a doctor and pharmacy, but is isn’t.  It just takes a few phone calls.  Please persevere.  If you’re currently taking addictive medications, you must first tell your doctor you want to be detoxed off of them before you begin LDN.  If they won’t detox you, find a detox specialist who will… also easy to find with a few calls.

I’ve included an article on LDN from Dr Mercola below.  It gives some information from a famous medical doctor regarding it’s purpose and safety.  LDN has no side effects, is non-addictive and totally safe.  Please have a good read.

Low-Dose Naltrexone (LDN): One of the RARE Drugs

that Actually Helps Your Body to Heal Itself

by Dr. Mercola

It is not often that I advocate the use of prescription drugs, but low-dose naltrexone (LDN) is one of those rare exceptions that may hold the promise of helping millions of people with cancer and autoimmune disease.

As a pharmacologically active opioid antagonist, LDN works by blocking opioid receptors, which in turn helps activate your body’s immune system.

How LDN Harnesses Your Own Body’s Chemistry to Fight Disease

The latest research in Experimental Biology and Medicine just confirmed that LDN does in fact target the opioid growth factor (OGF)/opioid growth factor receptor (OGFr) pathway to inhibit cell proliferation. Previous research by professor Ian S. Zagon of The Pennsylvania State University, who also conducted the Experimental Biology and Medicine study, found that OGF regulates the growth of cancer cells, and all cancer cells use the OGF-OGFr pathway in growth regulation.

It is through this mechanism that LDN is thought to exert its profound inhibitory effect on cancer growth.

Further, LDN also works with your body’s immune system through its interactions with your body’s endorphins. Though most commonly referenced in relation to you mood, endorphins also play a role in pain relief, immune system regulation, growth of cells and angiogenesis (the growth of blood vessels that feed a tumor).

Typically, LDN is taken at bedtime, which blocks your opioid receptors, as well as the reception of endorphins, for a few hours in the middle of the night. This is believed to up-regulate vital elements of your immune system by increasing your body’s production of metenkephalin and endorphins (your natural opioids), hence improving your immune function.

In addition to cancer, LDN has shown promise for the treatment of the following diseases:

Hepatitis C Diabetic neuropathies
Lupus Dermatomyositis (an inflammatory muscle disease)
Ulcerative colitis Multiple sclerosis
Autism Crohn’s disease
Chronic fatigue syndrome Alzheimer’s disease
HIV/AIDS Hasimoto’s thyroiditis
Irritable bowel syndrome (IBS) Parkinson’s disease
How can one substance impact so many different diseases? As written on the non-profit Web site LowDoseNaltrexone.org, which is an excellent resource for more information:

“The disorders listed above all share a particular feature: in all of them, the immune system plays a central role. Low blood levels of endorphins are generally present, contributing to the disease-associated immune deficiencies.”

Impressive Results in Cancer Treatment

In 1985, Dr. Bernard Bihari discovered LDN enhanced patients’ response to infection with HIV, the virus that causes AIDS. Years later he found that his patients with cancer and autoimmune disease also benefited from LDN.

Dr. Bihari has reportedly treated more than 450 cancer patients with LDN with promising results, including cancers of the bladder, breast, liver, lung, lymph nodes, colon, and rectum. According to Dr. Bihari, nearly a quarter of his patients had at least a 75 percent reduction in tumor size, and nearly 60 percent of his patients demonstrated disease stability. He believes LDN’s anti-cancer mechanism is likely due to an increase in the:

Number and density of opiate receptors on the tumor cell membranes, making them more responsive to the growth-inhibiting effects of the already present levels of endorphins, which in turn induces apoptosis (cell death) in the cancer cells
Absolute numbers of circulating cytotoxic T cells and natural killer cells, as well as killer cell activity
An impressive study released earlier this year exemplifies LDN’s potential anti-cancer effects, in this case to treat ovarian cancer.

The study found:

~~~LDN administered for six hours every two days reduced DNA synthesis and cell        replication in tissue culture
~~~Exposure to LDN in combination with cancer drugs had enhanced anti-cancer action
~~~Mice with established ovarian tumors treated with LDN had repressed tumor progression by reducing DNA synthesis and angiogenesis — but not altering cell survival, indicating it is non-toxic
~~~LDN combined with a chemotherapy drug, cisplatin, alleaviated the toxicity associated with cisplatin
~~~LDN treatment upregulated the expression of the opioid growth factor, which is the only opioid peptide that tends to inhibit cell growth of ovarian cancer cells
~~~Says Dr. Burton M. Berkson, MD, who has attested to achieving phenomenal results with low-dose naltrexone in both cancer patients and those with autoimmune diseases: “It is difficult for many to believe that one drug can accomplish so many tasks. But LDN does not treat symptoms as most drugs do. It actually works way “upstream” to modulate the basic mechanisms that result in the disease state.”

Your Doctor Probably Doesn’t Know About Low-Dose Naltrexone

LDN has been an FDA-approved drug for over two decades, conventionally used to treat drug- and alcohol addiction at doses of 50mg to 300mg. Much lower doses (3 to 4.5 mg) are used for LDN’s immunomodulating properties as discussed above, but it has not yet been submitted for FDA approval at this low dose. None of the pharmaceutical giants back it, as at an average price of $15 to $40 for a month’s supply, the income potential isn’t very promising.

This means there are no friendly sales reps visiting your doctor talking about the potential benefits of this drug in very low doses, and as a result very few physicians are aware of LDN. So, if your physician is not familiar with LDN, you will need to bring it up to him or her, or, alternatively, seek a health care provider who is already knowledgeable at using LDN as a form of treatment. There are a number of pharmacies and compounding pharmacies in the United States and Canada that are reliable sources of the compound in low-dose form.

CAUTION: Important LDN Points to Consider if You Use It

Avoid slow-release (SR) or timed-release naltrexone. You want to be sure the LDN you receive is in unaltered form that allows you to receive the full dose quickly. Slow-release formulas may not give you the full therapeutic effects.
Be aware of inactive fillers. Part of the LDN capsule will contain a “neutral” filler material, however there is some evidence to suggest that calcium carbonate as a filler could interfere with the absorption of LDN. So to be on the safe side, avoid LDN capsules that contain calcium carbonate fillers.
Ideally, if you are interested in using LDN as a potential treatment consult with a knowledgeable health care practitioner who can guide your therapy and also help you find a reliable compounding pharmacy.

SOURCE: http://articles.mercola.com/sites/articles/archive/2011/09/19/one-of-the-rare-drugs-that-actually-helps-your-body-to-heal-itself.aspx